Production activities

NSCEDI develops and produces medical immunobiological drugs (MIBD) of more than 40 items intended for the prevention of plague (plague vaccine), laboratory diagnostics of quarantine and especially dangerous infections, and indication of pathogens of these diseases. The center has copyright for 19 developments.

Along with the development of new MIBD, research is constantly being conducted to improve the effectiveness of drugs, improve technological processes, and search for new ways to immunodiagnostic quarantine and especially dangerous infections (development and production of PCR test systems).

Consumers in Kazakhstan: anti-plague stations, organization of the Ministry of Healthcare, veterinary service of the Ministry of Agriculture, diagnostic laboratories etc. NSCEDI products are also exported to Central Asian countries, Russia, Belarus, Ukraine, and Mongolia.

The quality of drugs is controlled by the Department of Biological and Technological Control – a testing laboratory accredited by СТ РК ИСО/МЭК 17025-2007. On the basis of NSCEDI, pre-registration tests of disinfectants, insecticides, and protective agents are conducted.

NCSEDI – National Collection and National Depository of especially dangerous microorganisms (RK government resolution No 850 «On the Republican collection of microorganisms» from July 30, 2002). With the introduction of the Central Reference Laboratory (CRL), the collection and long-term safe storage of collections of especially dangerous infections pathogens was ensured on the basis of a safe and secure depository. The collection located in BSL-3 of CRL contains pathogen strains (9000) of 6 species, and the pathogen movement is recorded in the PACS system.

The Center has a zoological museum and a parasitological collection.

The collection of fleas in scientific importance and quantity (400 species and subspecies) takes 4 place in the world and 2 in the CIS. Theriological collection — 105 species of mammals (6 thousand units of storage): carcasses, skins and skulls. Collections are used in research and in the training of students.

Training cadets using collections.

Another activity of NSCEDI is training. These are various types of courses: retraining of physicians, advanced training of doctors, biologists, laboratory assistants. For the first time, starting in 2016, retraining of veterinary specialists is carried out.

Bacteriological hall and field practice.

The NSCEDI training center enjoys an excellent reputation in the world. For example, with EU funding, 262 specialists from the CIS, Mongolia and the Caucasus were trained as part of ISTC projects in 2012-2014:

  • Tajikistan – 35
  • Kyrgyzstan – 58
  • Uzbekistan – 101
  • Azerbaijan – 4
  • Armenia – 2
  • Georgia – 3
  • Mongolia – 59

NSCEDI has a vivarium for breeding and keeping laboratory animals of the SPF category – the only one in the Republic of Kazakhstan. The main goal of the NSCEDI laboratory animal nursery is to breed and sell linear laboratory animals of the SPF category (Specific Pathogen Free) – outbred and inbred mice, rats, guinea pigs and rabbits, registration veterinary number of the Ministry of Agriculture of the Republic of Kazakhstan № KZ A/07/K-002.

NSCEDI Vivarium

The principles of humane use of laboratory animals are applied in vivariums.

The vivarium uses «clean room» technology (ISO 14-644) to maintain the microbiological and genetic cleanliness of animals.

NSCEDI has a local bioethical Commission that regulates research with biological materials.

NSCEDI annually conducts conferences, seminars, trainings and round tables on laboratory animal husbandry.

Consulting and methodological assistance

Visits are made to anti-plague stations, Department of the Public Health Protection Committee, NCE branches and the Department of Health.

The review and analysis is carried out on:

  • Annual APS Plans and Reports
  • APS living culture Museum plans and Reports
  • Examination of documents for obtaining a permit for APS laboratories to work with pathogens of I-II groups
  • Monthly information about the epizootic situation for the plague
  • Monthly data on the incidence of EDI in the world
  • Annual analytical report on plague and cholera

Information support and monitoring is carried out on:

  1. Monthly information for the Ministry of Health of the Republic of Kazakhstan:
  • «WHO data on the incidence of EDI in the world»
  • «Analysis of the epizootic situation of plague in the Republic of Kazakhstan» to assess the threats of the spread of EDI
  1. Weekly information on plague and cholera for the Ministry of Health of the Republic of Kazakhstan
  2. The publication of the journal «Quarantine and zoonotic infections in Kazakhstan»
  3. Issue and transfer of printed normative and methodological documentation to APS and DPHPC
  4. Access to resources of ScienceDirect, Scopus, Web of Science and SpringerLink.

Reference studies are conducted

  • All complex cases of suspected EDI, bioterrorism, or unknown EDI are diagnosed by NSCEDI;
  • Practical assistance to CA specialists on EDI (Kyrgyzstan).


Advances in biosafety and biosecurity are the development and implementation in NSCEDI and APS:

  1. Risk management systems (based on the international standard CWA 15793)
  2. Development and implementation of the biosafety manual (based on WHO guide 2004, 2006)
  3. Development of 5 computer analytical programs for assessing biosafety risks of biosecurity risks (during the functioning of CRL, when working with EDI pathogens, and for assessing the risks of SPPs (stationary problem points) for anthrax)
  4. Implementation of the PACS system (electronic pathogen control system) in the activities of the National Repository of EDI pathogens
  5. Physical protection of NSCEDI as a strategic object meets Kazakhstan and international standards


The Central Reference Laboratory (CRL), which has been put into operation, also serves to improve the biological safety of the country. This is:

— BSL-2 and BSL-3 laboratories with the ability to study a wide range of human and animal bacteria and viruses,

— strengthening sanitary protection of borders against the import of diseases,

— improved response to infectious disease outbreaks,

— use of modern technologies for the study of especially dangerous pathogens,

— staff training with the help of local and international partners,

— key role in the network of national and regional laboratories for work with especially dangerous human and animal pathogens,

— integrating public health and veterinary systems.

The biological safety for EDI is carried out by 9 anti-plague stations and NSCEDI. The last cases of plague in the Republic of Kazakhstan were registered in 2003.

Deployment of institutions of the antiplague service of the Republic of Kazakhstan

The creation of a joint Center with APS will increase the effectiveness of EDI monitoring and the epidemic well-being of the population by combining the scientific, methodological, training and production potential of NSCEDI with the experience of practical APS. This combination is rational taking into account possible risks and economic forecasts and will allow to:

  1. Implement a unified state policy in the field of comprehensive control of EDI according to the unified plan for system monitoring of plague foci and prevention of EDI, and innovative solutions to problems in this area
  2. Carry out constant professional monitoring of the performance of preventive work (disinsection and deratization)
  3. Methodologically ensure the expansion of the spectrum of APS-supervised infections that require preventive measures
  4. Implement a system of interagency interaction in the field of countering bioterrorism
  5. Rationalize purchases of equipment, disinfectants and consumables, taking into account possible risks and economic forecasts

The long-term experience of the anti-plague service of the EEU countries, where anti-plague organizations are a separate link in the health system, shows the feasibility of such structure and confirms the relevance of creating such Center.

Национальный научный центр особо опасных инфекций
Almaty city,
Zhakhanger street, 14

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